Long Term Potentiation (LTP) is the strengthening (or potentiation) of the synaptic connections between neurons. External events are represented in the brain as spatiotemporal patterns of neural activity, and it is these patterns of activity which must themselves be the agents of synaptic change. The location of storage, the engram of learning and memory, must therefore be found among those synapses which support activity-dependent changes in synaptic efficiency.[1] LTP has been shown to follow neural activation, both naturally and induced experimentally by applying a sequence of short, high-frequency stimulation to nerve cell synapses.