The pathway from CA1 to Subiculum (Sb) and on to the entorhinal cortex forms the principal output from the hippocampus. However, it is not a straightforward uni-directional pathway. The connection from CA1 - Sb follows a strict anatomical layout. The distal end of the CA1 region projects to the proximal end of the Sb, i.e. those cells nearest to the CA1 - Sb junction are connected, and those furthest apart are connected. Projections to EC follow a similar pattern, with distal CA1/proximal Sb projecting to the lateral EC while proximal CA1/distal Sb project to the medial EC. It should also be noted that the input to these cells from the EC follows the same pattern i.e., distal CA1/proximal Sb receives input from the lateral EC while proximal CA1/distal Sb receives input from medial EC. Thus two closed loop networks are present within the overall hippocampal network. These loops are further extended to perirhinal and post-rhinal cortices, as the Perirhinal Cortex projects to the lateral EC and receives returning projections while the post-rhinal cortex projects to and receives inputs from the medial EC.